Grape seed, or Vitis vinifera contains many health-promoting compounds, ranging from wrinkle reduction to pain relief. Grape seed extract can be applied topically or taken internally, and is the best known source of antioxidants available.

Flavonoids, specifically oligomeric procyanidins (OPCs), are present in grape seed extract, and provide extraordinary amounts of antioxidant protection. OPCs help prevent and repair capillary damage, and contains up to 50 times more protection against oxidants than vitamin E and vitamin C. These OPCs are similar to the compound pycnogenol in pine bark, and are sometimes mistakenly listed as pycnogenol in lists of ingredients.

Grape seed extract is thought to help with some circulatory disorders, such as varicose veins, diabetic retinopathy, chronic venous insufficiency, and poor circulation. It works by promoting circulation and protecting against free radical protection. Grape seed extract remains in the body for up to three days, unlike vitamin C and vitamin E, which are quickly excreted.

Resveratrol is also present in grape seed extract, acting as an anti-inflammatory agent. The resveratrol in grape seed extract can also lower triglyceride and cholesterol level, supply antioxidant protection, and possibly slow tumor growth. Cancer researchers are continuing to experiment with the use of grape seed extract in cancer fighting drugs.